Postinfluenza Environment Reduces Aspergillus fumigatus Conidium Clearance and Facilitates Invasive Aspergillosis In VivoArticle Published on 2022-12-202023-06-14 Journal: mBio [Category] Fulltext, 신종인플루엔자, [키워드] antifungal immunity Aspergillus fumigatus host-pathogen interactions influenza A virus Innate immunity Invasive pulmonary aspergillosis Monocytes Neutrophils Pathogenesis phagocytosis phagolysosome phagolysosome maturation Superinfection. [DOI] 10.1128/mbio.02854-22 PMC 바로가기
Aspergillus detection in airways of ICU COVID-19 patients: To treat or not to treat?ICU COVID-19 환자의 기도에서 아스페르길루스 검출: 치료할 것인가, 말 것인가?Case Reports Published on 2022-08-012022-09-11 Journal: Journal de mycologie médicale [Category] COVID19(2023년), SARS, 바이오마커, 치료기술, [키워드] absence airway Antifungal Antifungal treatment Antigen Aspergillus Aspergillus fumigatus Atypical COVID-19 Culture difficulty galactomannan highlight ICU ICU patient ICU Patients Intubated invasive Invasive pulmonary aspergillosis IPA management mechanically ventilated mechanically ventilated patient mechanically ventilated patients outcome Patient patients PCR Pneumonia pulmonary aspergillosis radiological Respiratory samples respiratory tract sample respiratory tract samples risk SARS CoV SARS CoV-2 SARS-CoV-2 SARS-CoV-2 pneumonia SARS-CoV-2. severe COVID-19 Symptomatology treat [DOI] 10.1016/j.mycmed.2022.101290 PMC 바로가기 [Article Type] Case Reports
Novel Galactopyranoside Esters: Synthesis, Mechanism, In Vitro Antimicrobial Evaluation and Molecular Docking Studies새로운 갈락토피라노사이드 에스테르: 합성, 메커니즘, 시험관 내 항균성 평가 및 분자 도킹 연구Article Published on 2022-06-272022-09-12 Journal: Molecules [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] 6LU7 activity ADMET studies antifungal agents antimicrobial antimicrobial agents antiviral drugs Aspergillus fumigatus binding energy Bioavailability catalyzed conducted distribution drug-likeness dynamics simulation in vitro indicated inhibitor metabolism methyl α-D-galactopyranoside esters molecular molecular docking novel one-step acylation. PDB produced protease reactivity SARS-CoV-2 sequence supported synthesis the SARS-CoV-2 these compound Toxicity [DOI] 10.3390/molecules27134125 PMC 바로가기 [Article Type] Article
Investigation of the value of precipitins in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients with a positive marker for Aspergillus speciesAspergillus 종에 대한 양성 마커를 가진 중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 환자에서 침전물의 값 조사Article Published on 2022-05-282022-09-11 Journal: Medical mycology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, 치료기술, 치료제, [키워드] A. fumigatus acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 acute respiratory syndrome coronavirus-2 Antigen antigens Aspergillus Aspergillus fumigatus assays Biomarker Biomarkers Bronchoalveolar lavage Characteristics Clinical data Co-infection collected colonization coronavirus Culture electrosyneresis ELISA galactomannan Hospitalized house hypersensitivity pneumonitis ICU ICU patient ICU Patients Infection intensive care intensive care unit investigation male management marker median microbial Patient patients performed positive precipitins Prevalence pulmonary aspergillosis purified qPCR reported respiratory respiratory sample Respiratory samples SARS CoV SARS CoV-2 SARS-CoV-2 SARS-CoV-2 patient SARS-CoV-2 patients screened serology assays Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus significantly higher similarities similarity somatic antigen study population suggested survival rate t-test tracheal Tracheal aspirates tracheal aspirates. [DOI] 10.1093/mmy/myac031 PMC 바로가기 [Article Type] Article
Population genomics confirms acquisition of drug-resistant Aspergillus fumigatus infection by humans from the environment Research Published on 2022-04-252022-10-05 Journal: Nature Microbiology [Category] 변종, 유전자 메커니즘, [키워드] A. fumigatus acquisition Analysis Aspergillus fumigatus biosynthetic canonical caused clade defined driver drug resistance drug-resistant drugs fungal genes encoding Genetic Genomic analysis Genotype Human increasingly Infection Ireland isolate isolates loci majority numbers of patient Occurrence pathogen pathway Patient population genomics Positive selection Recombination Region resistance mechanisms second selective sweep susceptible susceptible patient transmitted understanding viral respiratory [DOI] 10.1038/s41564-022-01091-2 [Article Type] Research
In vivo imaging of invasive aspergillosis with 18 F-fluorodeoxysorbitol positron emission tomography18 F-플루오로데옥시소르비톨 양전자 방출 단층 촬영을 사용한 침습성 아스페르길루스증의 생체 내 영상화Article Published on 2022-04-082022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] aspergillosis Aspergillus Aspergillus fumigatus Brain can be used caused clinical information clinical outcomes Combination Critical detect Diagnosis Diagnostic method differential diagnosis Hematologic malignancy Immunocompromised patient Immunocompromised patients induce Infection infections Influenza Influenza virus invasive Localization Lungs Mouse models muscle muscles pet Pneumonia positron emission Positron emission tomography pulmonary aspergillosis pulmonary infiltrate pulmonary infiltrates Staphylococcus aureus time-consuming tomography Viral Viral pneumonia [DOI] 10.1038/s41467-022-29553-5 PMC 바로가기 [Article Type] Article
COVID-19-associated pulmonary aspergillosis in ICU patients in a German reference centre: Phenotypic and molecular characterisation of Aspergillus fumigatus isolatesObservational Study Published on 2022-04-012022-10-05 Journal: Mycoses [Category] 임상, [키워드] A. fumigatus Analysis Aspergillus Aspergillus fumigatus azole-resistance CAPA prevalence Care caused characterisation Clustering collected Compound COVID-19 COVID-19 associated pulmonary aspergillosis Critically ill distribution Genotype genotyping hospital ICU patient increased mortality intensive care unit invasive isolate isolates marker microsatellite typing. molecular Mutation nine Patient PCR performed polyclonal Prevalence reported strain susceptibility with COVID-19 [DOI] 10.1111/myc.13430 PMC 바로가기 [Article Type] Observational Study
Regulation of gliotoxin biosynthesis and protection in Aspergillus species아스 페르 길 루스 종에서의 글리 톡신 생합성 및 보호의 조절Research Article Published on 2022-01-182022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Analysis approach aspergillosis Aspergillus Aspergillus fumigatus Aspergillus oryzae best cause colonisation component conserved disease Disease progression enzyme expresse expression expression of gene expression pattern facilitate fungal Genes genetic determinant genetic determinants Genome Glia homolog homologs human immune response identify Immune cell impair include involved kojic acid mechanism metabolism modulated mycotoxin negative regulation neutralising nidulan nidulans observé occur Occurrence pathogenicity producing regulate required responses RNA-sequencing screened secrete secretion sensitivity significantly sulfur Taking TFS toxic effect toxic effects transcription factor transcription factors transcriptional transcriptional response virulence [DOI] 10.1371/journal.pgen.1009965 PMC 바로가기 [Article Type] Research Article
COVID-19 Associated Pulmonary Aspergillosis: Diagnostic Performance, Fungal Epidemiology and Antifungal SusceptibilityArticle Published on 2022-01-182022-10-30 Journal: Journal of Fungi [Category] COVID-19, [키워드] Antifungal antifungal susceptibility testing Antifungal treatment aspergillosis Aspergillus Aspergillus flavus Aspergillus fumigatus Aspergillus nidulans Aspergillus niger BAL Bronchoalveolar lavage changes in Cohort contribute Coronavirus disease 2019 coronavirus disease 2019 (COVID-19)-associated pulmonary aspergillosis (CAPA) COVID-19 Culture Diagnosis diagnostic tests Epidemiology fungal fungal diagnosis highlight hospital ICU patient incidence increased mortality involved majority marker Microscopy performance positive sample pulmonary raise respiratory specimen serum suffered treated [DOI] 10.3390/jof8020093 PMC 바로가기 [Article Type] Article
The prevalence of early‐ and late‐onset bacterial, viral, and fungal respiratory superinfections in invasively ventilated COVID‐19 patientsResearch Article Published on 2022-01-042022-10-04 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 치료기술, [키워드] Aspergillus fumigatus Bacteria Bacterial Bronchoalveolar lavage chronic obstructive Cohort coronavirus disease Coronavirus disease 2019 correlation COVID‐19 COVID‐19 patient Day develop Diabetes Mellitus fungal fungal pathogen herpes simplex Infection intensive care intubation invasive ventilation invasively ventilated patient investigated Klebsiella Klebsiella pneumoniae mechanical ventilation obesity pathogen Pathogens Patient Pneumonia Prevalence prevalent Probability Pseudomonas aeruginosa pulmonary disease respiratory coinfections respiratory virus severe acute respiratory syndrome coronavirus 2 significantly higher tested Ventilated virus [DOI] 10.1002/jmv.27548 PMC 바로가기 [Article Type] Research Article